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PORCENTAGEM REDUZIDA DE MICB NA SUPERFÍCIE DE MONÓCITOS E ALTOS NÍVEIS DE MOLÉCULAS SOLÚVEIS EM INDIVÍDUOS PORTADORES DO ALELO MICB*004

Doi: 10.47094/978-65-6036-515-5/7

PALAVRAS CHAVE: MICB. Moléculas de estresse. Monócitos.

KEYWORDS: MICB. Stress molecules. Monocytes.

ABSTRACT:
The MICA and MICB genes encode surface molecules constitutively expressed on epithelial cells, fibroblasts, and monocytes. However, under stress, all cells, with the exception of neurons, can express them. They interact exclusively with the activating receptors NKG2D, present on NK and TCD8+ cells, resulting in cytotoxicity of the target cell. However, they can be cleaved and thus block the action of these receptors and the cytotoxic machinery. Objective: The objective of this study was to analyze the number of monocytes expressing MICB on the surface and the levels of this soluble molecule in the cell supernatant (sMICB).

Autores

  • A. M. M

  • C. F. B

  • E. C

  • I. M

  • J. S

  • L. A

  • M. A

  • N. A. C

  • V. A. O

  • BRAZ

  • CASTELLI

  • CASTRO

  • CIRIACO

  • FERRAZ

  • GOLIM

  • MACHADO

  • OGATA

  • TINI

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