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POLIMORFISMO DE BASE ÚNICA DOS GENES ECA 2 E TNF-A EM PACIENTES COM A FORMA CARDÍACA DA DOENÇA DE CHAGAS

Doi: 10.47094/978-65-6036-515-5/31

PALAVRAS CHAVE: Doença de Chagas. Trypanosoma cruzi. rs2074192. SNP 1031C.

KEYWORDS: Chagas disease. Trypanosoma cruzi. rs2074192. SNP 1031C.

ABSTRACT:
Introduction: Chagas disease (CD) is caused by the protozoan Trypanosoma cruzi, endemic in 21 countries in Latin America. It is estimated that 6 to 8 million people in Latin America are infected. Clinical manifestations occur in two phases, acute and chronic. Chronicity may be asymptomatic or indeterminate and symptomatic or cardiac, digestive and mixed forms - related to clinical signs. Host genetic factors are quite relevant and may explain the heterogeneity found in patients living with the disease in endemic areas. Objective: to verify the frequency of single nucleotide polymorphisms (SNP) of the ACE 2 and TNF-alpha genes, associated with hypertension and inflammation, in two chronic forms of CD, cardiac and indeterminate, and associate them with anthropometric and clinical data.

Autores

  • B. C

  • C

  • R

  • S

  • CARVALHO

  • LUCHEIS BALDINI

  • MATTOS DOS SANTOS

  • SUEMI KUROKAWA

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