EXPRESSÃO DA VIA DE SINALIZAÇÃO PI3K/ AKT/ MTOR NO CÂNCER DE MAMA ASSOCIADO À INFECÇÃO PELO PAPILOMAVÍRUS HUMANO

Doi: 10.47094/XXXSBM.2025/9

PALAVRAS CHAVE: HPV. Carcinogênese mamário. Oncogene.

KEYWORDS: HPV. Breast carcinogenesis. Oncogene.

ABSTRACT:
Introduction: Breast cancer is the second most common cancer worldwide, and an estimated 71,000 new cases will be reported in Brazil by 2025 [1]. Risk factors for this cancer include family history, mutations in the BRCA1 and BRCA2 genes, lifestyle habits, and viral infections [2]. Human papillomavirus (HPV) has a high potential to interact with signaling pathways, dysregulating the cell cycle and promoting alterations capable of contributing to carcinogenesis [3]. The PI3K/AKT/mTOR signaling cascade is more active in 30-40% of breast carcinomas and contributes to increased cell proliferation, angiogenesis, and metastasis [4]. Objective: Therefore, the present study sought to analyze the influence of HPV on the expression of genes in the PI3K/AKT/mTOR pathway in breast cancer.

Autores

• Antonio Carlos de Freitas

• Beatriz Eda de Oliveira Isídio

• Bianca de França São Marcos

• Daffany Luana dos Santos

• David Beltrán Lussón

• Gabriel Romulo Parente da Silva

• Isabelle Silva Simões

• Kaynne Gabriely Lins

• Pedro Henrique Bezerra Fontes

• Stephanie Loureiro Leão

• Vanessa Emanuelle Pereira Santos