Publicar

EXPRESSÃO DIFERENCIAL DE FOXO4 EM LINHAGENS CELULARES DE CÂNCERES DE MAMA E PULMÃO TRANSFECTADAS COM ONCOGENES DO HPV

Doi: 10.47094/XXXSBM.2025/20

PALAVRAS CHAVE: Fator de transcrição. Papilomavírus Humano. Transfecção.

KEYWORDS: Transcription factor. Human papillomavirus. Transfection.

ABSTRACT:
Introduction: Human papillomavirus (HPV) is the main etiological agent of cervical cancer and its presence has been detected in other types of cancer, such as lung and breast cancer [1]. Studies have been conducted to understand the role of the virus in breast and lung carcinogenesis. The HPV oncoproteins E5, E6, and E7 interact with and regulate various signaling pathways and transcription factors, potentially exerting protumor or antitumor roles, depending on the target [1]. The FOXO4 transcription factor acts as a tumor suppressor, promoting apoptosis and inducing cell cycle arrest [2]. Downregulation of this protein is associated with the development of breast and lung cancer [3][4]. Objective: Therefore, this study aimed to analyze the expression of FOXO4 in lung and breast cancer cell lines individually transfected with the HPV oncogenes E5, E6, and E7.

Autores

  • Antonio Carlos de Freitas

  • Beatriz Eda de Oliveira Isídio

  • Bianca de França São Marcos

  • Daffany Luana dos Santos

  • David Beltrán Lussón

  • Gabriel Romulo Parente da Silva

  • Isabelle Silva Simões

  • Kaynne Gabriely Lins

  • Pedro Henrique Bezerra Fontes

  • Stephanie Loureiro Leão

  • Vanessa Emanuelle Pereira Santos

Download