A INFLUÊNCIA DOS NÍVEIS DE P-SELECTINA NAS COMPLICAÇÕES CLÍNICAS DA ANEMIA FALCIFORME: UMA REVISÃO SISTEMÁTICA

Doi: 10.47094/XXXSBM.2025/28

PALAVRAS CHAVE: Hemoglobinopatia. SELP. P-selectina.

KEYWORDS: Hemoglobinopathy. SELP. P-selectin.

ABSTRACT:
Introduction: Sickle cell anemia (SCA) is a genetic disorder characterized by the presence of anomalous hemoglobin S. SCA is associated with high levels of hemolysis and vaso-occlusion, triggering clinical manifestations such as vaso-occlusive crises (VOC), acute chest syndrome (ACS), and stroke [2]. Thus, the pathophysiology of SCA is closely linked to P-selectin, an adhesion molecule encoded by the SELP gene, as it contributes to the inflammatory process by promoting leukocyte and platelet aggregation, aggravating endothelial dysfunction [2]. Objective: To conduct a literature review on P-selectin levels and their impact on the clinical complications of SCA.

Autores

• Ednayran da Silva Galdino

• Gabriela da Silva Arcanjo

• Jocelin Santa Rita Bisneto

• Laíza Maria Ferreira Souza

• Marcos André Cavalcanti Bezerra

• Vanessa Ellen de Moura Luna