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CARDIOTOXICIDADE POR ANTRACICLINAS: REVISÃO INTEGRATIVA DOS ASPECTOS FISIOPATOLÓGICOS E ESTRATÉGIAS DE PREVENÇÃO

Doi: 10.47094/978-65-284-0234-2/2

PALAVRAS CHAVE: Antraciclinas. Cardiotoxicidade. Quimioterápico.

KEYWORDS: Anthracyclines. Cardiotoxicity. Chemotherapeutic agent.

ABSTRACT:
INTRODUCTION: Anthracyclines are effective chemotherapeutic agents for the survival of cancer patients, but they are associated with cardiovascular events such as ventricular dysfunction, heart failure, arrhythmias, and sudden death. Cardiotoxic mechanisms involve DNA damage and reactive oxygen species, resulting in myofibril loss, atrophy, and cell death. For cancer survival, early recognition of these complications is fundamental. However, standardized screening protocols and consolidated cardioprotective strategies in clinical practice are still lacking. OBJECTIVES: To review the main pathophysiological mechanisms of anthracycline-induced cardiotoxicity and discuss strategies for prevention and early detection in cancer patients.

Autores

  • Adriana Araujo Sepp

  • Ana Luiza Portilho Soares

  • Irwing Franck de Almeida Alves

  • Júlia Ayres Cavalcante

  • Átilla Costa e Silva

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