Publicar

POTENCIAL IMPACTO DE SEQUÊNCIAS DE REPETIÇÃO EM TANDEM (STRs) NA PROGRESSÃO AO ÓBITO EM PACIENTES COM COVID-19

Doi: 10.47094/978-65-284-0218-2/3

PALAVRAS CHAVE: Sequências de Repetição em Tandem. COVID-19.

KEYWORDS: Tandem Repeat Sequences. COVID-19.

ABSTRACT:
INTRODUCTION: Tandem repeat sequences (STRs) are repetitive segments of DNA, mostly 2-6 base pairs, associated with different genetic disorders and phenotypic characteristics¹. However, there is little understanding of their impact on immunomodulation and the progression of infectious diseases. Recently, humanity experienced a global crisis generated by SARS-CoV-2, a virus that affected more than 700 million people, resulting in approximately 7 million deaths from COVID-19². Even with efforts to understand this disease, there are no reports on the impact of STRs present in the genomes of patients that may be implicated in the progression of COVID-19. OBJECTIVE: This study aims to evaluate the association between germline STRs and death in patients with COVID-19.

Autores

  • João L. L. P. Pitta

  • Luydson R. S. Vasconcelos

  • Beatriz S. T. Melo

  • Camila S. Lins

  • Matheus A. Bomfim

  • Túlio L. Campos

Download