POTENCIAL USO DA SALIVA COMO RECURSO CONFIÁVEL PARA DIAGNÓSTICO E MONITORAMENTO DA INFECÇÃO POR SARS-CoV-2

Doi: 10.47094/978-65-88958-33-9/35-45

PALAVRAS CHAVE: saliva. Coronavírus. COVID-19.

KEYWORDS: saliva. Coronavirus. COVID-19.

ABSTRACT:
This work portrays, through a literature review, updated information on the use of saliva as a sample for the detection of the SARS-CoV-2 virus. The search were carried out in the PubMed, Scielo, Science Direct, and Scopus databases aimed at scientific articles in an international scope published in 2020 and 2021. The descriptors used for the search for journals were viral infections, diagnosis, COVID-19 and saliva. Saliva can be used for the direct detection of SARS-CoV-2, the quantification of specific immunoglobulins produced against this pathogen, and for the assessment of the patient' s innate immune response. In addition, a more detailed knowledge of the potential changes in the salivary proteome in this disease may allow the identification of new diagnostic biomarkers. By conducting an appropriate sample collection and employing appropriate processing and testing methods, saliva can provide relevant clinical information about COVID-19, and can be included in the guidelines for sample collection for diagnosis, management and control of COVID- 19.

Autores

• Danilo Resende dos Santos

• Leydianne Leite de Siqueira Patriota

• Lidiane Pereira de Albuquerque

• Suellem Maria Arrais de Oliveira

• Thiago Henrique Napoleão

• Éric Ribeiro Silva