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02 - MASTÓCITOS: OS GRANDES REGULADORES DA RESPOSTA INFLAMATÓRIA

Doi: 10.47094/978-65-284-0596-1/14-17

PALAVRAS CHAVE: Intestino - Inflamação. Doenças inflamatórias intestinais. Histamina. Gastroenterologia. Imunidade.

KEYWORDS: Intestine – Inflammation. Inflammatory bowel diseases. Histamine. Gastroenterology. Immunity.

ABSTRACT:
Mast cell biology
Mast cells are resident immune system cells widely distributed in tissues that interface with the external environment, such as the skin, gastrointestinal tract, respiratory airways, and genitourinary system. They are also found surrounding blood vessels, lymphatic vessels, and nerve endings—a strategic positioning that allows them to respond rapidly to various environmental stimuli (Seneviratne; Maitland; Afrin, 2017).
Their primary function is to act as immune sentinels, participating in defense against parasites, tissue healing, angiogenesis, and the inflammatory response.
However, when activated inappropriately or excessively, mast cells become significant amplifiers of inflammation, releasing a wide variety of mediators capable of affecting virtually every system in the body.

Autores

  • Ana Luiza de Rezende Ferreira Mendes

  • Beatriz Paiva Rocha

  • Cintia Galeno Araújo

  • Francisca Maria da Silva

  • Geam Carles Mendes dos Santos

  • Greice Kelly Costa de Sena

  • Josseana Holanda Montezuma

  • Laíze Moreira de França

  • Luiza Camila Rodrigues Gomes

  • Maria Marta Souza do Nascimento

  • Rachel Holanda Montezuma

  • Ranielle Barbosa Saraiva

  • Tiago Holanda Montezuma

  • Valéria Silva de Lima

  • Ydinara Luttiana Paz de Oliveira

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