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03 - HISTAMINA NO TRATO GASTROINTESTINAL

Doi: 10.47094/978-65-284-0596-1/18-21

PALAVRAS CHAVE: Intestino - Inflamação. Doenças inflamatórias intestinais. Histamina. Gastroenterologia. Imunidade.

KEYWORDS: Intestine – Inflammation. Inflammatory bowel diseases. Histamine. Gastroenterology. Immunity.

ABSTRACT:
Histamine in the gastrointestinal tract: far beyond digestion
When we think of histamine, it is common to associate it solely with allergic reactions. However, a significant portion of this amine's activity actually takes place in the gastrointestinal tract. The intestine is not merely a site for nutrient absorption but also a vital immunological organ and a primary location where histamine is produced, released, and metabolized, and where it exerts its biological effects.
In the gastrointestinal tract, histamine plays a role in regulating gastric acid secretion, intestinal motility, mucosal fluid secretion, intestinal barrier integrity, and communication between the immune system and the enteric nervous system. These effects occur through the activation of H1, H2, and H4 receptors found on enterocytes, smooth muscle cells, blood vessels, immune cells, mast cells, and enteric neurons (Smolinska et al., 2022; Fabisiak et al., 2026).

Autores

  • Ana Luiza de Rezende Ferreira Mendes

  • Beatriz Paiva Rocha

  • Cintia Galeno Araújo

  • Francisca Maria da Silva

  • Geam Carles Mendes dos Santos

  • Greice Kelly Costa de Sena

  • Josseana Holanda Montezuma

  • Laíze Moreira de França

  • Luiza Camila Rodrigues Gomes

  • Maria Marta Souza do Nascimento

  • Rachel Holanda Montezuma

  • Ranielle Barbosa Saraiva

  • Tiago Holanda Montezuma

  • Valéria Silva de Lima

  • Ydinara Luttiana Paz de Oliveira

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