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06 - INTERFERÊNCIA DE FÁRMACOS TIREOSTÁTICOS E TERAPIAS HORMONAIS NA REGULAÇÃO BIOQUÍMICA DO EIXO HIPOTÁLAMO-HIPÓFISE: IMPLICAÇÕES TOXICOLÓGICAS E PERICIAIS

Doi: 10.47094/978-65-284-0602-9/85-97

PALAVRAS CHAVE: Eixo hipotálamo-hipófise-tireoide. Fármacos tieostáticos. Terapia hormonal. Toxicologia.

KEYWORDS: Hypothalamic-pituitary-thyroid axis. Antithyroid drugs. Hormone therapy. Toxicology.

ABSTRACT:
This study aims to evaluate the interference of antithyroid drugs and hormone therapies in the biochemical regulation of the Hypothalamic-Pituitary-Thyroid axis and its toxicological and forensic implications. To this end, a descriptive and exploratory literature review will be conducted through searches in scientific databases such as PubMed/PMC, ScienceDirect, Scopus, Frontiers, and LWW Journals, using Health Sciences Descriptors (DeCS) related to the HPT axis, antithyroid drugs, hormone therapies, and forensic toxicology, encompassing studies that integrate biochemical and forensic aspects, in both English and Portuguese. It is expected that understanding the biochemical mechanisms and laboratory repercussions will be essential for biomedical and forensic practice, enabling the accurate identification of intoxications and the appropriate monitoring of hormone therapies, thereby contributing to patient safety and the elucidation of medicolegal cases.

Autores

  • Amanda Karine de Sousas

  • Arkellau Kenned Silva Moura

  • Caio Cesar Vieira Rocha

  • Dárcio Luiz de Sousa Júnior

  • Helvis Eduardo Oliveira da Silva

  • Iasminy Macedo

  • Isadora Gomes de Souza

  • Jaiane Maria Silva

  • Janês Inês de Brito

  • José Mateus Alves Moreira

  • Júlio César Silva**

  • Leandro Marques Correia

  • Lucijane Barbosa Batista

  • Luís Pereira-de-Morais

  • Maria Cecília da Costa Nunes

  • Marina Micaelle Rodrigues Siqueira

  • Mateus Duarte Dumont de Matos

  • Natália Pinheiro Fabricio Formiga

  • Raimundo Luiz Silva Pereira

  • Tainá Lucas freire

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