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ALTERAÇÕES NA MICROBIOTA INTESTINAL DE ADULTOS COM TRANSTORNO DEPRESSIVO MAIOR

Doi: 10.47094/CESMED.2025/15

PALAVRAS CHAVE: Microbioma Gastrointestinal. Transtorno Depressivo Maior. Transtornos Mentais.

KEYWORDS: Gastrointestinal Microbiome. Major Depressive Disorder. Mental Disorders.

ABSTRACT:
INTRODUCTION: Major depressive disorder (MDD) is a prevalent and debilitating psychiatric condition characterized by persistent symptoms of sadness, loss of interest, hypothymia, anhedonia, abulia, and cognitive difficulties. Recent studies indicate that the gut microbiota, composed of trillions of microorganisms, plays a fundamental role in mental health, influencing the development of psychiatric disorders such as depression and anxiety. The bidirectional communication between the gut and the brain, known as the gut-brain axis, can be altered by dysbiosis (microbial imbalance), contributing to the worsening of depressive symptoms. OBJECTIVES: To investigate changes in the gut microbiota of adults with major depressive disorder (MDD) and explore how these changes may influence its pathophysiology.

Autores

  • Giulia Rota Carneiro

  • Luciana Torquato Fiuza Cardoso

  • Luis Claudio Bochenek

  • Luiza Azzi Vaz de Campos

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