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DIABETES MELLITUS TIPO 2 COMO FATOR DE RISCO PARA A DOENÇA DE PARKINSON: UMA REVISÃO SISTEMÁTICA DA LITERATURA

Doi: 10.47094/CESMED.2025/27

PALAVRAS CHAVE: Associação. Diabetes Mellitus tipo II. Doença de Parkinson. Fator de risco.

KEYWORDS: Association. Type II Diabetes Mellitus. Parkinson' s Disease. Risk Factor.

ABSTRACT:
INTRODUCTION: Parkinson' s disease (PD) is an irreversible and progressive neurological condition that affects 8.5 million people worldwide. PD is a proteinopathy characterized by malformation and aggregation of alpha-synuclein. The main clinical manifestations are: resting tremor, muscle rigidity, bradykinesia and akinesia, postural changes, a festinated gait, limited facial expression, and non-motor symptoms such as depression, cognitive changes, and autonomic disturbances. The prevalence of type 2 diabetes mellitus (T2DM) is 370 million people worldwide. Insulin sensitivity in the liver and peripheral tissues is reduced, leading to decreased insulin receptor signaling and impaired glucose absorption. Combined, these alterations in systemic homeostasis compromise organ function. T2DM and PD are prevalent diseases affecting an aging population. Emerging evidence suggests biological links between the two. OBJECTIVES: This study aims to investigate the literature on patients with type II diabetes mellitus as a risk factor for the development of Parkinson' s disease.

Autores

  • Ana Paula de Melo Guimarães

  • Ana Paula de Melo Guimarães

  • Jacqueline Cássia de Castro

  • Ysis Gomes Campos

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