ATIVIDADE ANTIBACTERIANA DA HIDRALAZINA E SEUS DERIVADOS: UMA REVISÃO INTEGRATIVA

Doi: 10.47094/978-65-6036-962-7/98-107

PALAVRAS CHAVE: Antibacteriana. Derivados. Hidralazina. Mecanismo antibacteriano.

KEYWORDS: Antibacterial. Derivatives. Hydralazine. Antibacterial mechanism.

ABSTRACT:
Hydralazine (HZD) is a direct vasodilator drug, its mechanism of action involves the relaxation of the smooth muscles of blood vessels, resulting in a decrease in blood pressure (BP) used since the mid-20th century. Furthermore, recent studies have suggested that HZD, together with its derivatives, has pharmacological properties beyond its traditional indications, including antimicrobial activity. In this sense, the objective of this work is to review the existing literature on the antibacterial activity of hydralazine and its derivatives, analyzing the proposed mechanisms, and the efficacy against different bacterial strains and the challenges associated with these compounds.

Autores

• Camila Bezerra Nobre

• Carla Mikevely de Sena Bastos

• Cicera Datiane de Morais Oliveira-Tintino

• Daniel Sampaio Alves

• Daniely Sampaio Arruda Tavares

• Dárcio Luiz de Sousa Júnior

• Jade Oliveira Brito Peixoto

• Júlio César Silva

• Leandro Marques Correia

• Luiz Roberto Torres de Almeida

• Maria Aparecida Santiago da Silva

• Marina Micaelle Rodrigues

• Mylene Teles de Lima

• Olivia Caroline Maia de Moura

• Paula Patrícia Marques Cordeiro

• Priscilla Ramos Freitas

• Raimundo Luiz Silva Pereira

• Rakel Olinda Macedo da Silva

• Vanessa Lima Bezerra

• Vinícius Bezerra de Freitas Pereira