ESTUDO COMPARATIVO DA VETORIZAÇÃO ENTRE A DOXORRUBICINA LIVRE E EM NANOPARTÍCULAS POLIMÉRICAS PH SENSÍVEIS PARA CÉLULAS MCF-7: UMA REVISÃO SISTEMÁTICA

Doi: 10.47094/978-65-6036-962-7/108-129

PALAVRAS CHAVE: Nanopartículas. Polímeros. Doxorrubicina. Câncer de mama.

KEYWORDS: Nanoparticles. Polymers. Breast Cancer. Doxorubicin.

ABSTRACT:
Introduction: Breast cancer is one of the main causes of death from cancer in women, ranking second in the world, and is more prevalent in women over 55. Conventional treatment, which does not exclusively target tumor cells, results in side effects such as cardiotoxicity and cytotoxicity of healthy cells, hindering adherence and the effectiveness of chemotherapy. Objective: To compare in vitro studies on the efficiency of free doxorubicin versus pH-sensitive polymeric nanoparticles in targeting the drug to the MCF-7 cell line.

Autores

• Brenda da Silva Vilar Freitas

• Carlos Renan Batista Tomaz

• Daniel Sampaio Alves

• Iasminy Macedo

• Israele Fernandes Rodrigues

• Jade Oliveira Brito Peixoto

• José Mateus de Jesus Castro

• Júlio César Silva

• Luís Pereira-de-Morais

• Maria Gabriely de Lima Silva

• Mylene Teles de Lima

• Olivia Caroline Maia de Moura

• Patrícia Pereira Tavares de Alcântara

• Priscilla Ramos Freitas

• Rakel Olinda Macedo da Silva

• Romário Matheus Conceição de Oliveira

• Thaís Pereira Lopes

• Vinícius Bezerra de Freitas Pereira