MECANISMOS DE RESISTÊNCIA BACTERIANA: O PAPEL DAS BOMBAS DE EFLUXO E NOVAS ALTERNATIVAS TERAPÊUTICAS

Doi: 10.47094/978-65-6036-962-7/130-146

PALAVRAS CHAVE: Antibioticos. Resistência bacteriana. Alternativas terapêuticas.

KEYWORDS: Antibiotics. Bacterial resistance. Therapeutic alternatives.

ABSTRACT:
INTRODUCTION
Although the discovery of antibiotics has contributed significantly to improvements in health, the emergence and spread of resistant microorganisms has become a major challenge for researchers worldwide, leading to concerns of an imminent global infectious disease crisis (ABDEL-AZIEM; BAAIU; EL-SAWY, 2022; MOSTAFAEI et al, 2023; MITCHELTREE et al, 2023). Currently, it is estimated that infections caused by resistant microorganisms are responsible for approximately 700,000 deaths per year and this rate is expected to increase sharply by 2050 (PAPKOU et al, 2020).

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