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27 -RESISTÊNCIA ANTIMICROBIANA DE Stenotrophomonas maltophilia EM INFECÇÕES RELACIONADAS À ASSISTÊNCIA À SAÚDE: UMA REVISÃO SISTEMÁTICA

Doi: 10.47094/978-65-284-0495-7/286-295

PALAVRAS CHAVE: Stenotrophomonas maltophilia. Resistência antimicrobiana. Infecções Relacionadas à Assistência à Saúde.

KEYWORDS: Stenotrophomonas maltophilia. Antimicrobial resistance. Healthcare-associated infection.

ABSTRACT:
In recent years, Stenotrophomonas maltophilia has emerged as a relevant opportunistic pathogen in healthcare-associated infections (HAIs), due to its intrinsic resistance to multiple antimicrobial agents and the limited therapeutic options available. This study aimed to analyze the antimicrobial resistance of S. maltophilia isolates from HAIs in light of the current literature. This is a systematic review structured based on the PICO strategy and conducted according to PRISMA guidelines. The search was performed in the electronic databases PubMed, Springer, and the Virtual Health Library (VHL), using controlled DeCS descriptors: “Stenotrophomonas maltophilia”, “Drug Resistance, Microbial”, and “Cross Infection”, combined using the Boolean operator AND. A total of 155 articles were identified, of which 142 were excluded after applying eligibility criteria, resulting in 13 studies included in the final analysis. High levels of antimicrobial resistance were observed, varying according to the antimicrobial class. Trimethoprim-sulfamethoxazole remained the main therapeutic option, although reports of emerging resistance were identified. Minocycline showed low resistance rates, while levofloxacin demonstrated variable effectiveness. In contrast, ceftazidime exhibited high resistance rates. In conclusion, S. maltophilia represents an emerging pathogen of high clinical relevance, highlighting the importance of microbiological surveillance and the rational use of antimicrobials.

Autores

  • Ana Júlia Melo de Vasconcelos Arruda

  • Antônio Maurício Alves Neto

  • Ariane Pereira Da Costa

  • Brenda Rocha Lima

  • Dyana Leal Veras

  • Fábio André Brayner

  • Igor Soares Gouveia

  • Janderson Weydson Lopes Menezes da Silva

  • Lucas Gabriel Bento de Souza Aleixo Correia

  • Luiz Carlos Alves

  • Mario Alves Silva Junior

  • Rayane Maria Castro da Silva

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