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28 - PREVALÊNCIA GLOBAL DOS PRINCIPAIS GENES DE CARBAPENEMASES EM KLEBSIELLA PNEUMONIAE: UMA REVISÃO SISTEMÁTICA

Doi: 10.47094/978-65-284-0495-7/296-304

PALAVRAS CHAVE: Klebsiella pneumoniae. Gene de Resistência. Carbapenemase

KEYWORDS: Klebsiella pneumoniae. Gene Resistance. Carbapenemase

ABSTRACT:
Carbapenem resistance in Enterobacteriaceae, particularly in Klebsiella pneumoniae, represents a significant challenge to public health, especially in hospital settings. This study aimed to analyze the prevalence of the main carbapenemase genes in clinical isolates of this species in studies published in scientific literature. A predominance of the genes blaKPC, blaNDM, and blaOXA-48 was observed, with variations according to geographic context. The blaKPC gene was more frequent in Latin America, while blaNDM predominated in South Asia. In contrast, blaOXA-48 showed greater relevance in Europe, whereas genes such as blaImp-4 were rarely reported. These findings indicate that the distribution of these genes is associated with epidemiological factors and the post-pandemic context, reinforcing the importance of molecular surveillance in controlling antimicrobial resistance.

Autores

  • Ana Júlia Melo de Vasconcelos Arruda

  • Ariane Pereira da Costa

  • Brenda Rocha Lima

  • Dyana Leal Veras

  • Fábio André Brayner dos Santos

  • Guilherme Delmondes Nascimento

  • Igor Soares Gouveia

  • Janderson Weydson Lopes Menezes da Silva

  • Lucas Gabriel Bento de Souza Aleixo Correia

  • Luíz Carlos Alves

  • Rayane Maria Castro da Silva

  • Saulo Cockles Crisanto da Silva

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