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69 - DIETA BASEADA EM PLANTAS NA DOENÇA HEPÁTICA ESTEATÓTICA ASSOCIADA À DISFUNÇÃO METABÓLICA (MASLD): MECANISMOS, EVIDÊNCIAS E PERSPECTIVAS

Doi: 10.47094/978-65-284-0495-7/641-650

PALAVRAS CHAVE: Resistência à insulina. Lipogênese de novo. Proteínas vegetais.

KEYWORDS: Insulin resistance. De novo lipogenesis. Plant proteins.

ABSTRACT:
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is the most prevalent chronic hepatic disease worldwide, affecting approximately 38% of adults and imposing an increasing clinical and economic burden. In the absence of a universally approved pharmacotherapy, dietary interventions play a central role in disease management. The plant-based diet (PBD) emerges as a clinically relevant strategy, acting simultaneously on multiple pathophysiological targets: modulation of de novo lipogenesis (DNL) via inhibition of SREBP-1c and acetyl-CoA carboxylase (ACC); activation of the nuclear receptor PPAR-? with consequent stimulation of mitochondrial ?-oxidation; protein substitution with impact on the mTOR/mitophagy/insulin resistance axis; and restoration of the gut microbiota with increased production of short-chain fatty acids (SCFAs). This narrative review analyzes the biochemical mechanisms underlying the efficacy of PBD in MASLD, integrating the recommendations of the EASL-EASD-EASO guidelines (2024) and the Brazilian SBEM-SBH-ABESO Guideline (2023). The results confirm that PBD is a mechanistically grounded, clinically effective intervention aligned with the state of the art in non-pharmacological management of MASLD.

Autores

  • Gislaine Juk Santos

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