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135 - RESPOSTA IMUNE NA LEISHMANIOSE VISCERAL CANINA

Doi: 10.47094/978-65-284-0495-7/1208-1218

PALAVRAS CHAVE: Leishmania. Imunologia. Resposta inata.

KEYWORDS: Leishmania. Immunology. Innate response.

ABSTRACT:
Visceral leishmaniasis is a vector-borne zoonosis caused by a protozoan of the genus Leishmania, with dogs being the main reservoir in urban areas, such that the prevalence of canine infection precedes the risk of transmission to the human population. The different clinical manifestations of leishmaniasis are determined by the host's immune response, mediated by the responses of type 1 or type 2 helper T lymphocytes, which may or may not favor the presence of infection. The surveillance service faces a major challenge in understanding asymptomatic dogs and false negatives through conventional tests performed by the public system. This issue must be resolved, as it may be creating silent reservoirs of disease. Dogs with clinical symptoms characteristic of leishmaniasis are almost always reactive to serological tests, while seropositivity is less frequent in asymptomatic dogs. Therefore, there is a need to search for assays for detection in this group of animals.

Autores

  • Andréa Regina Alves da Rocha Diniz

  • Antônio Maurício Alves Neto

  • Ariane Pereira da Costa

  • Brenda Rocha Lima

  • Fábio André Brayner

  • Igor Soares Gouveia

  • Janderson Weydson Lopes Menezes da Silva

  • Lucas Gabriel Bento de Souza Aleixo Correia

  • Luiz Carlos Alves

  • Rayane Maria Castro da Silva

  • Rosemary Gonçalves de Aguiar

  • Saulo Cockles Crisanto da Silva

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