CORRELAÇÃO ENTRE O USO CRÔNICO DE INIBIDORES DE BOMBA DE PRÓTONS E A REDUÇÃO DA ABSORÇÃO DE VITAMINA B12

Doi: 10.47094/978-65-6036-670-1/878-885

PALAVRAS CHAVE: Inibidores de Bomba de Prótons. Vitamina B12. Deficiência.

KEYWORDS: Proton Pump Inhibitors.Vitamin B 12. Deficiency.

ABSTRACT:
Prolonged and excessive use of PPIs is widely associated with decreased absorption of vitamin B12, a compound of extreme importance for proper metabolic function, as well as for the development of red blood cells, and therefore its deficiency is greatly harmful to health. The objective of this study was to evaluate studies on this correlation published between 2017 and 2024 through a selection of studies indexed in the databases of the National Library of Medicine (PUBMED) and the Virtual Health Library (VHL). The results point to potential side effects of the action of this class of drugs linked to their chronic use and in high doses. Such effects arise essentially from the increase in gastric pH and the decrease in the activity of parietal cells. Thus, actions to better control the use of these drugs should be studied and instituted in order to modify this harmful scenario.

Autores

• Ana Beatriz Alves Lima

• Ana Carolina Linard Carneiro

• Ana Emília Santos de Queiroz

• Anaylle Vieira Lacerda de Oliveira

• Anna Karolyna Carvalho Vilarouca de Freitas

• Gabriele Kelly Bezerra Bessa

• Maria Clécia Dantas de Freitas

• Maria Luiza de Lima Vale

• Maria Luysa Cartaxo Gonçalves

• Marina Gomes de Carvalho

• Milleny Vitória Nunes de Araújo

• Mirella Soares da Silva