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99 - ABORDAGEM MULTIALVO DA OBESIDADE: INTEGRAÇÃO ENTRE MECANISMOS FISIOPATOLÓGICOS E COMPOSTOS BIOATIVOS VEGETAIS

Doi: 10.47094/978-65-284-0654-8/998-1006

PALAVRAS CHAVE: Obesidade. Fitoterapia. Abordagem multialvo.

KEYWORDS: Obesity. Phytotherapy. Multi-target approach.

ABSTRACT:
Obesity is a chronic, multifactorial, and multisystem disease characterized by the interaction of inflammatory, metabolic, neuroendocrine, and behavioral alterations. Given this complexity, phytotherapy has emerged as a complementary therapeutic strategy due to the presence of bioactive compounds capable of modulating multiple pathophysiological mechanisms involved in the disease. This chapter aimed to discuss the integration between the main pathophysiological pathways of obesity and the pharmacological effects of medicinal plant species with therapeutic potential, emphasizing the multi-target phytotherapeutic approach. The chapter was developed from an integrative literature review conducted in the PubMed/MEDLINE, SciELO, and LILACS databases. The evidence was organized according to the main pathophysiological mechanisms of obesity, including chronic inflammation, neuroendocrine modulation, glucose and lipid metabolism, oxidative stress, and hydroelectrolytic balance. The findings indicate that Passiflora incarnata, Baccharis trimera, Phaseolus vulgaris, Aloe ferox, Fucus vesiculosus, and Equisetum giganteum exhibit complementary pharmacological mechanisms, reinforcing the potential of the multi-target phytotherapeutic approach as a rational strategy for obesity management and for the development of evidence-based herbal formulations.

Autores

  • Gisele Lopes de Oliveira

  • Laise Moura Orlandi

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