Publicar

EIXO HIPOTÁLAMO-HIPÓFISE: A INFLUÊNCIA DOS DISRUPTORES ENDÓCRINOS NO DESENVOLVIMENTO PUBERAL

Doi: 10.47094/978-65-284-0273-1/9

PALAVRAS CHAVE: Disruptores endócrinos. Infância. Puberdade precoce.

KEYWORDS: Endocrine disruptors. Childhood. Precocious puberty.

ABSTRACT:
Introduction: Gonadarche corresponds to the reactivation of the hypothalamic-pituitary-gonadal axis, characterized by the pulsatile secretion of GnRH, increased LH/FSH, and production of sex hormones. It is a central event in hormonal maturation and the onset of physiological changes characteristic of this phase. In recent decades, a trend towards the early onset of this process has been observed. Objectives: To evaluate the relationship between exposure to chemical-biological factors on the activation of the hypothalamic-pituitary axis and the outcomes associated with precocious puberty.

Autores

  • Anna Júlia Boaventura Souza Pires

  • Bruno Cassiano Lima

  • Giovanna Luiza Tavares Caetano

  • Maria Fernanda Antunes

Download