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08 - A LÚPUS ERITEMATOSO SISTÊMICO NA GESTAÇÃO: PLANEJAMENTO PRÉ- CONCEPCIONAL, FARMACOTERAPIA COM HIDROXICLOROQUINA E VIGILÂNCIA MATERNO-FETAL

Doi: 10.47094/978-65-284-0587-9/60-67

PALAVRAS CHAVE: Obstetrícia. Parto (Obstetrícia) - Aspectos psicológicos. Enfermagem obstétrica. Gravidez. Humanização dos serviços de saúde.

KEYWORDS: Obstetrics. Childbirth (Obstetrics) – Psychological aspects. Obstetric nursing. Pregnancy. Humanization of health services.

ABSTRACT:
1. INTRODUCTION: THE REPRODUCTIVE PARADIGM IN SYSTEMIC LUPUS ERYTHEMATOSUS
Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disease that predominantly affects women during their reproductive years (PATTON; SIDDIQUE; LAL, 2025). Historically, pregnancy in women with SLE was discouraged due to high rates of disease flare-ups, recurrent fetal loss, and maternal mortality. However, improvements in risk stratification, the consolidation of preconception planning, and the use of safe immunomodulators have transformed the obstetric prognosis (ZHANG et al., 2025; UTHURRIAGUE et al., 2025).
Despite these advances, pregnancy in the context of lupus remains a highly complex scenario. The interplay between the physiological immunological changes of pregnancy and the autoimmune mechanisms of SLE predisposes patients to severe complications, including early-onset preeclampsia, intrauterine growth restriction (IUGR), extreme prematurity, neonatal lupus, and fetal death (SUN; LI; LI, 2025; CAJAMARCA-BARON et al., 2025).
Qualitative and grounded theory studies highlight that the meaning these women attribute to motherhood is permeated by the fear of disease reactivation and the imperative need for reproductive planning shared with the healthcare team (SOUZA et al., 2025). This chapter addresses the pathophysiological basis, pharmacotherapy—with an emphasis on the protective role of hydroxychloroquine—the management of neonatal lupus, and the multiprofessional care provided to pregnant women with SLE.

Autores

  • Ana Sheila Chagas Pinho

  • Elisângela da Silva Morais

  • Francisca Leonilda Sampaio Rodrigues

  • Francisca Moraes da Silva

  • Maria Betânia da Silva

  • Maria Edna da Silva Bandeira

  • Marli de Oliveira Nunes

  • Mary Grace Magalhães de Araújo

  • Michelle Leane Santana da Silva

  • Tamires Alves dos Santos

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