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113 - IMPACTOS DA ESCASSEZ DE PENICILINA NO CONTROLE DA SÍFILIS CONGÊNITA: DESAFIOS EPIDEMIOLÓGICOS E LIÇÕES PARA O SISTEMA DE SAÚDE

Doi: 10.47094/978-65-284-0452-0/1126-1133

PALAVRAS CHAVE: Sífilis Congênita. Penicilina. Saúde Pública. Vigilância Epidemiológica. Pré-Natal.

KEYWORDS: Congenital Syphilis. Penicillin. Public Health. Epidemiological Surveillance. Prenatal Care.

ABSTRACT:
Sepsis is a major global public health problem associated with high morbidity and mortality rates, prolonged hospitalizations, and elevated healthcare costs. Early recognition and rapid implementation of clinical protocols are essential for reducing complications and improving clinical outcomes. In this context, different countries have developed specific guidelines to standardize sepsis management in hospital settings. This study aimed to comparatively analyze sepsis management protocols adopted in Brazil and Portugal, emphasizing their clinical recommendations, care strategies, and impacts on patient safety. This is a narrative literature review and documentary analysis of clinical guidelines conducted in the Scientific Electronic Library Online (SciELO), PubMed/MEDLINE, Virtual Health Library (VHL), and Google Scholar databases, in addition to official documents from the Latin American Sepsis Institute (ILAS), the Portuguese Directorate-General of Health (DGS), and the Surviving Sepsis Campaign. The results showed convergence between the protocols regarding the importance of early identification, rapid administration of antimicrobials, hemodynamic monitoring, and implementation of care bundles. However, differences were observed regarding organization of care flows, laboratory criteria, and institutional implementation strategies. It is concluded that standardization of sepsis protocols represents an important strategy for strengthening patient safety and improving healthcare quality in hospital services. Congenital syphilis remains a major public health problem, especially in developing countries, and is associated with high rates of fetal and neonatal morbidity and mortality. Benzathine penicillin is the treatment of choice for preventing vertical transmission of syphilis and is considered a fundamental strategy in disease control. However, episodes of shortage of this medication have significantly compromised prevention and treatment actions in several healthcare systems. This study aimed to analyze the impacts of penicillin shortage on the control of congenital syphilis, emphasizing epidemiological challenges and lessons for the healthcare system. This is an integrative literature review associated with documentary analysis of epidemiological bulletins and official documents from the Ministry of Health and the World Health Organization. The results showed an increase in congenital syphilis cases during periods of medication shortage, difficulties in implementing adequate prenatal treatment, and expansion of healthcare vulnerabilities. It was also observed that failures in logistical management, insufficient early screening, and inequalities in access to healthcare services contributed to worsening of the epidemiological scenario. It is concluded that strengthening epidemiological surveillance, prenatal care, and pharmaceutical supply chain management is essential for effective control of congenital syphilis and prevention of future shortages.

Autores

  • Andreia Lany Moura do Nascimento

  • Antônia de Cássia Abreu Silva

  • Araci Acácia Ribeiro Silva

  • Benedita Elizabete de Aguiar

  • Cláudia Maria Amorim

  • Francisca Lenice Pinto

  • Francisca Moraes da Silva

  • Ian Paiva Rodrigues

  • Lucimeire Barbosa Viana dos Santos

  • Maria Ariane Soares Mendes

  • Maria Elieuza Abreu Vasconcelos

  • Maria das Graças Pereira Lima

  • Márcia Beatriz Abreu de Amorim

  • Tatiana Alves Abreu Santos

  • Valdenia Silva Melo

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